Product Name :
Bradykinin (2-9)
Description:
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.
CAS:
16875-11-9
Molecular Weight:
904.02
Formula:
C44H61N11O10
Chemical Name:
5-[(diaminomethylidene)amino]-2-{2-[(1-{3-hydroxy-2-[3-phenyl-2-(2-{[1-(pyrrolidine-2-carbonyl)pyrrolidin-2-yl]formamido}acetamido)propanamido]propanoyl}pyrrolidin-2-yl)formamido]-3-phenylpropanamido}pentanoic acid
Smiles :
NC(N)=NCCCC(NC(=O)C(CC1C=CC=CC=1)NC(=O)C1CCCN1C(=O)C(CO)NC(=O)C(CC1C=CC=CC=1)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1)C(O)=O
InChiKey:
ZZHVXIPXTCBVBE-UHFFFAOYSA-N
InChi :
InChI=1S/C44H61N11O10/c45-44(46)48-20-8-16-30(43(64)65)51-38(59)32(24-28-13-5-2-6-14-28)52-40(61)35-18-10-22-55(35)42(63)33(26-56)53-37(58)31(23-27-11-3-1-4-12-27)50-36(57)25-49-39(60)34-17-9-21-54(34)41(62)29-15-7-19-47-29/h1-6,11-14,29-35,47,56H,7-10,15-26H2,(H,49,60)(H,50,57)(H,51,59)(H,52,61)(H,53,58)(H,64,65)(H4,45,46,48)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.|Product information|CAS Number: 16875-11-9|Molecular Weight: 904.02|Formula: C44H61N11O10|Chemical Name: 5-[(diaminomethylidene)amino]-2-{2-[(1-{3-hydroxy-2-[3-phenyl-2-(2-{[1-(pyrrolidine-2-carbonyl)pyrrolidin-2-yl]formamido}acetamido)propanamido]propanoyl}pyrrolidin-2-yl)formamido]-3-phenylpropanamido}pentanoic acid|Smiles: NC(N)=NCCCC(NC(=O)C(CC1C=CC=CC=1)NC(=O)C1CCCN1C(=O)C(CO)NC(=O)C(CC1C=CC=CC=1)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1)C(O)=O|InChiKey: ZZHVXIPXTCBVBE-UHFFFAOYSA-N|InChi: InChI=1S/C44H61N11O10/c45-44(46)48-20-8-16-30(43(64)65)51-38(59)32(24-28-13-5-2-6-14-28)52-40(61)35-18-10-22-55(35)42(63)33(26-56)53-37(58)31(23-27-11-3-1-4-12-27)50-36(57)25-49-39(60)34-17-9-21-54(34)41(62)29-15-7-19-47-29/h1-6,11-14,29-35,47,56H,7-10,15-26H2,(H,49,60)(H,50,57)(H,51,59)(H,52,61)(H,53,58)(H,64,65)(H4,45,46,48)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed.{{Leptomycin B} web|{Leptomycin B} Anti-infection|{Leptomycin B} Biological Activity|{Leptomycin B} In Vivo|{Leptomycin B} manufacturer|{Leptomycin B} Cancer} Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized.{{PF-06821497} site|{PF-06821497} Epigenetics|{PF-06821497} Protocol|{PF-06821497} In stock|{PF-06821497} custom synthesis|{PF-06821497} Cancer} The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection.PMID:35901518 In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8).|Products are for research use only. Not for human use.|
