Product Name :
Drinabant
Description:
Drinabant (AVE1625) is an orally active CB1 receptor antagonist. Drinabant (AVE1625) inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.
CAS:
358970-97-5
Molecular Weight:
497.38
Formula:
C23H20Cl2F2N2O2S
Chemical Name:
N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methanesulfonamide
Smiles :
CS(=O)(=O)N(C1CN(C1)C(C1C=CC(Cl)=CC=1)C1C=CC(Cl)=CC=1)C1C=C(F)C=C(F)C=1
InChiKey:
IQQBRKLVEALROM-UHFFFAOYSA-N
InChi :
InChI=1S/C23H20Cl2F2N2O2S/c1-32(30,31)29(21-11-19(26)10-20(27)12-21)22-13-28(14-22)23(15-2-6-17(24)7-3-15)16-4-8-18(25)9-5-16/h2-12,22-23H,13-14H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Drinabant (AVE1625) is an orally active CB1 receptor antagonist. Drinabant (AVE1625) inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.|Product information|CAS Number: 358970-97-5|Molecular Weight: 497.38|Formula: C23H20Cl2F2N2O2S|Chemical Name: N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methanesulfonamide|Smiles: CS(=O)(=O)N(C1CN(C1)C(C1C=CC(Cl)=CC=1)C1C=CC(Cl)=CC=1)C1C=C(F)C=C(F)C=1|InChiKey: IQQBRKLVEALROM-UHFFFAOYSA-N|InChi: InChI=1S/C23H20Cl2F2N2O2S/c1-32(30,31)29(21-11-19(26)10-20(27)12-21)22-13-28(14-22)23(15-2-6-17(24)7-3-15)16-4-8-18(25)9-5-16/h2-12,22-23H,13-14H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Formaldehyde dehydrogenase} web|{Formaldehyde dehydrogenase} Biological Activity|{Formaldehyde dehydrogenase} In Vivo|{Formaldehyde dehydrogenase} manufacturer|{Formaldehyde dehydrogenase} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Cephalexin} web|{Cephalexin} Penicillin-binding protein (PBP)|{Cephalexin} Purity & Documentation|{Cephalexin} In stock|{Cephalexin} manufacturer|{Cephalexin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23664186 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|AVE1625 (10 mg/kg orally once daily), combined with Olanzapine (HY-14541) attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility. AVE1625 (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 (HY-15084B) or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory.|Products are for research use only. Not for human use.|
