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IDH1 monoclonal antibody
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Monoclonal antibody to IDH1 R132H mutation for use with IHC applications IDH1 (Isocitrate Dehydrogenase 1) is an enzyme found in the cytoplasm and perixosomes.{{2089251-47-6} medchemexpress|{2089251-47-6} Purity & Documentation|{2089251-47-6} In Vitro|{2089251-47-6} manufacturer} IDH1 is a metabolic gene that is often mutated in human cancer. It is involved in metabolic and cellular pathways, specifically the Krebs cycle.{{2748220-93-9} site|{2748220-93-9} Purity & Documentation|{2748220-93-9} Formula|{2748220-93-9} custom synthesis} Mutations are frequently found in diffuse low-grade gliomas and secondary glioblastomas, but rarely in primary glioblastomas.PMID:30521236 The most notable mutation in this enzyme is replacing amino acid arginine with histidine at codon 132 (R132H). Formalin-fixed paraffin-embedded glioblastoma tissue stained using Enzo’s IDH1 antibody . IHC staining was performed on an automated Leica BOND III. Formalin-fixed paraffin-embedded glioblastoma tissue stained using Enzo’s IDH1 antibody . IHC staining was performed on an automated Leica BOND III.
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| Alternative Name Isocitrate dehydrogenase 1 | Application IHC | Application Notes The IDH1 antibody can be used to qualitatively identify the presence of IDH1 R132H protein mutation in FFPE tissue sections using IHC test methods.For IHC applications: Dilute the concentrate as appropriate in antibody diluent, and then apply 150 µL to the slide, as indicated in the user’s IHC protocol. | Formulation Liquid. In Tris buffer, pH 7.5, containing 1% BSA and | Host Mouse | Immunogen R132H mutant site | Isotype IgG | Recommendation Dilutions/Conditions Immunohistochemistry (1:50-1:200)Optimal conditions must be determined individually for each application. | Species Reactivity Human | UniProt ID O75874 | Unit of Measure (UM) µl
