Product Name :
Physostigmine
Description:
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer’s disease. Physostigmine is also an antidote for anticholinergic poisoning.
CAS:
57-47-6
Molecular Weight:
275.35
Formula:
C15H21N3O2
Chemical Name:
(3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-methylcarbamate
Smiles :
CN1CC[C@]2(C)[C@H]1N(C)C1=CC=C(C=C21)OC(=O)NC
InChiKey:
PIJVFDBKTWXHHD-HIFRSBDPSA-N
InChi :
InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sunvozertinib} medchemexpress|{Sunvozertinib} Btk|{Sunvozertinib} Technical Information|{Sunvozertinib} In Vitro|{Sunvozertinib} manufacturer|{Sunvozertinib} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Mefenamic acid} MedChemExpress|{Mefenamic acid} Immunology/Inflammation|{Mefenamic acid} Biological Activity|{Mefenamic acid} In Vivo|{Mefenamic acid} manufacturer|{Mefenamic acid} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32993405
Additional information:
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer’s disease. Physostigmine is also an antidote for anticholinergic poisoning.|Product information|CAS Number: 57-47-6|Molecular Weight: 275.35|Formula: C15H21N3O2|Chemical Name: (3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-methylcarbamate|Smiles: CN1CC[C@]2(C)[C@H]1N(C)C1=CC=C(C=C21)OC(=O)NC|InChiKey: PIJVFDBKTWXHHD-HIFRSBDPSA-N|InChi: InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Physostigmine (Eserine; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice. Physostigmine (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.|Products are for research use only. Not for human use.|
