Product Name :
TCO-PEG4-biotin
Description:
TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
CAS:
2183440-30-2
Molecular Weight:
614.79
Formula:
C29H50N4O8S
Chemical Name:
(4Z)-cyclooct-4-en-1-yl N-(14-5-[(3aS,4S,6aR)-3a,6a-dihydrogenio-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido-3,6,9,12-tetraoxatetradecan-1-yl)carbamate
Smiles :
O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NCCOCCOCCOCCOCCNC(=O)OC1CCCC=CCC1 |c:40|
InChiKey:
OADGBCNDNVFPDA-MSCWDKBPSA-N
InChi :
InChI=1S/C29H50N4O8S/c34-26(11-7-6-10-25-27-24(22-42-25)32-28(35)33-27)30-12-14-37-16-18-39-20-21-40-19-17-38-15-13-31-29(36)41-23-8-4-2-1-3-5-9-23/h1-2,23-25,27H,3-22H2,(H,30,34)(H,31,36)(H2,32,33,35)/b2-1-/t23?,24-,25-,27-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 2183440-30-2|Molecular Weight: 614.79|Formula: C29H50N4O8S|Chemical Name: (4Z)-cyclooct-4-en-1-yl N-(14-5-[(3aS,4S,6aR)-3a,6a-dihydrogenio-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido-3,6,9,12-tetraoxatetradecan-1-yl)carbamate|Smiles: O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NCCOCCOCCOCCOCCNC(=O)OC1CCCC=CCC1 |c:40||InChiKey: OADGBCNDNVFPDA-MSCWDKBPSA-N|InChi: InChI=1S/C29H50N4O8S/c34-26(11-7-6-10-25-27-24(22-42-25)32-28(35)33-27)30-12-14-37-16-18-39-20-21-40-19-17-38-15-13-31-29(36)41-23-8-4-2-1-3-5-9-23/h1-2,23-25,27H,3-22H2,(H,30,34)(H,31,36)(H2,32,33,35)/b2-1-/t23?,24-,25-,27-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Pyrimethamine Autophagy |Shelf Life: ≥12 months if stored properly.LL-37 amide manufacturer |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32907512 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.Products are for research use only. Not for human use.|
