Product Name :
WZ8040
Description:
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors.
CAS:
1214265-57-2
Molecular Weight:
481.01
Formula:
C24H25ClN6OS
Chemical Name:
N-3-[(5-chloro-2-[4-(4-methylpiperazin-1-yl)phenyl]aminopyrimidin-4-yl)sulfanyl]phenylprop-2-enamide
Smiles :
CN1CCN(CC1)C1C=CC(=CC=1)NC1=NC(SC2=CC(=CC=C2)NC(=O)C=C)=C(Cl)C=N1
InChiKey:
KIISCIGBPUVZBF-UHFFFAOYSA-N
InChi :
InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors.|Product information|CAS Number: 1214265-57-2|Molecular Weight: 481.Fomepizole Protocol 01|Formula: C24H25ClN6OS|Chemical Name: N-3-[(5-chloro-2-[4-(4-methylpiperazin-1-yl)phenyl]aminopyrimidin-4-yl)sulfanyl]phenylprop-2-enamide|Smiles: CN1CCN(CC1)C1C=CC(=CC=1)NC1=NC(SC2=CC(=CC=C2)NC(=O)C=C)=C(Cl)C=N1|InChiKey: KIISCIGBPUVZBF-UHFFFAOYSA-N|InChi: InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Toripalimab site |Shelf Life: ≥360 days if stored properly.PMID:33317653 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
