Product Name :
AZ191
Description:
AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.
CAS:
1594092-37-1
Molecular Weight:
429.52
Formula:
C24H27N7O
Chemical Name:
N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-ylpyrimidin-2-amine
Smiles :
CN1CCN(CC1)C1=CC(OC)=C(C=C1)NC1N=C(C=CN=1)C1=CN(C)C2C=NC=CC=21
InChiKey:
ZYVXTMKTGDARKR-UHFFFAOYSA-N
InChi :
InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.|Product information|CAS Number: 1594092-37-1|Molecular Weight: 429.SR9011 Vitamin D Related/Nuclear Receptor 52|Formula: C24H27N7O|Chemical Name: N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-ylpyrimidin-2-amine|Smiles: CN1CCN(CC1)C1=CC(OC)=C(C=C1)NC1N=C(C=CN=1)C1=CN(C)C2C=NC=CC=21|InChiKey: ZYVXTMKTGDARKR-UHFFFAOYSA-N|InChi: InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (69.Certolizumab pegol web 85 mM).PMID:32033942 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZ191 (0.01-60μM; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC50s of 3.183 μM and 1.279 μM, respectively. AZ191 (1-5 μM; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.|Products are for research use only. Not for human use.|
